荧光爱好者周刊(第三十九期)

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荧光爱好者周刊(第三十九期)

荧光爱好者周刊(第三十九期)#

Fluoresce M'lady: A novel near infrared reversibly switchable fluorescent protein PENELOPE enhances super-res live-cell imaging
Fluoresce M'lady: A novel near infrared reversibly switchable fluorescent protein PENELOPE enhances super-res live-cell imaging

欢迎阅读本期荧光领域学术动态周报。本周,荧光技术在生物临床诊断环境食品监测以及新型光电材料研发方面取得了多项突破性进展。以下是详细内容:


一、 荧光成像与临床医疗突破#

Communications Biology】 Label-free human skin imaging with enhanced molecular contrast via time-resolved fluorescence and advanced phasor analysis#

摘要: 传统的临床皮肤成像在区分多种内源性荧光分子时面临挑战。本研究利用多光子显微镜(MPM)结合时间分辨荧光成像和先进的相位分析(Phasor Analysis),成功实现了人体皮肤中角蛋白、黑色素及游离/结合态NADH的有效解离。这种无标记成像策略不仅能绘制不同肤色及代谢状态下的分子图谱,还为精准评估皮肤疾病及监控治疗效果提供了强有力的工具。

文献Ranjit, Suman等, Communications Biology, doi<10>.1038/s42003-025-09427-4

Materials Today Chemistry】 Surface engineering quantum dots emitting agents for NIR-II fluorescence imaging-guided rapid diagnosis of bone fracture#

摘要: 本研究开发了三种具有低毒性和高荧光量子产率的近红外二区(NIR-II)银基量子点,并利用表面工程技术制备了光稳定性良好的聚苯乙烯微球。实验证明,其中AgAuSe PS探针在活体内表现出优异的组织穿透深度(>3mm)和高信噪比。在小鼠模型中,该探针仅需10分钟即可实现骨折的高对比度实时可视化成像,为骨折的无创快速诊断提供了新方案。

文献Sha Liu等, Materials Today Chemistry, 10.1016/j.mtchem.2025.103285

International Journal of Colorectal Disease】 Deep impact analysis of surgical strategy changes guided by indocyanine green fluorescence angiography in laparoscopic low anterior resection for rectal cancer#

摘要: 该研究探讨了在直肠癌手术中,吲哚菁绿荧光血管造影(ICG-FI)对改变手术计划的具体影响因素。通过对临床病例的分析,研究人员评估了患者年龄、肿瘤位置及血管状况如何影响外科医生利用荧光导航实时调整手术切除边缘,从而显著提升了手术的精准度和安全性,减少了术后并发症风险。

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文献Qiu, Xuan等, International Journal of Colorectal Disease, 10.1007/s00384-025-05065-8

Cancers】 Recovery of IR700 Fluorescence After Near-Infrared Photoimmunotherapy: Discovery and Mechanistic Insights#

摘要: 近红外光免疫疗法(NIR-PIT)使用IR700偶联抗体。研究发现,在治疗后存在“早期荧光恢复”现象。本研究通过深入的机制探索,揭示了IR700分子在光照后的物理化学变化及其在肿瘤微环境中的动态过程。这一发现对于精确控制光动力剂量和实时监测治疗进度具有重要的临床参考价值。

文献Hideki Tanaka等, Cancers, 10.3390/cancers18010162

Cancers】 Fluorescence-Guided Surgery in Pediatric Oncology: Current Practice and Future Directions#

摘要: 儿科肿瘤常因紧邻重要结构而难以切除。本文系统回顾了荧光导航手术(FGS)在儿科肿瘤中的现状,重点介绍了吲哚菁绿(ICG)等示踪剂的应用。文章指出,荧光成像能有效提升肿瘤边缘的识别度,降低健康组织损伤,并对未来针对儿童生理特征设计更特异的荧光分子探针进行了展望。

文献Dominique C. Simons等, Cancers, 10.3390/cancers18010149

Analytical Chemistry】 Development of a Label-Free Fluorescence Strategy for Sensitive and Site-Specific Measurement of RNA Inosine Modification in Breast Tissues#

摘要: 肌苷(I)修饰对RNA成熟至关重要。研究者开发了一种基于氰乙基化诱导延伸终止和滚环扩增(PG-RCA)的无标记荧光检测策略。该方法灵敏度极高(LOD达67.97 aM),能准确量化单细胞水平的RNA肌苷。更重要的是,它能成功区分临床乳腺癌组织与正常组织的肌苷表达水平差异,为癌症辅助诊断提供了新思路。

文献Su Jiang等, Analytical Chemistry, 10.1021/acs.analchem.5c06035

Chinese Chemical Letters】 Electronic tuning of cyanine for highly specific dual ratiometric NIR-II fluorescence/photoacoustic imaging of H2S2 in vivo#

摘要: 通过电子修饰策略,本研究设计了针对二硫化氢(H2S2)的NIR-II荧光/光声双模态比率型探针。该探针(H2S2-4)在小鼠腹膜炎及后肢感染模型中,实现了对内源性H2S2动态变化的精确监测。该研究证明了电子调节策略在开发高特异性荧光探针中的有效性。

文献Zhenni Lin等, Chinese Chemical Letters, 10.1016/j.cclet.2025.112339

Molecules】 Evaluation of the Performance of New Fluorescence Immunoassay POCTs for Determining the Value of Vitamin D in Whole Blood#

摘要: 维生素D水平是骨健康及免疫功能的关键指标。本研究评估了一种新型荧光免疫分析即时检测(POCT)系统在全血中检测维生素D的性能。研究结果显示,该系统具有良好的准确性和快速响应能力,极大地简化了临床筛查流程。

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文献Alice Palermiti等, Molecules, 10.3390/molecules31010130

Microchemical Journal】 DNA-based nanomaterials for fluorescence imaging of tumor-associated biomolecules#

摘要: 本文综述了DNA纳米材料在肿瘤相关生物分子荧光成像中的最新进展。DNA凭借其可编程性和生物相容性,可作为构建多功能纳米平台的理想骨架。文章探讨了DNA纳米探针在早期癌症诊断、靶向递送及实时成像中的设计原则及未来发展趋势。

文献Wenjun Zhu等, Microchemical Journal, 10.1016/j.microc.2025.116723


二、 荧光传感器:环境、食品与工业检测#

Sensors and Actuators B: Chemical】 Improved laser-induced fluorescence instrument via chemical modulation for OH radical measurement: High-sensitivity detection and interference evaluation#

摘要: 大气中的OH自由基具有极低浓度和高活性,精准测量极为困难。本研究提出并验证了一种基于化学调制的激光诱导荧光(CM-LIF)探测系统。通过系统优化化学滴定池(CTC)参数,OH去除效率超过99%,探测限达到1.78 × 10^5 cm⁻³。该系统在复杂的大气环境下展示了优异的抗干扰能力,为评估大气氧化性和二次污染转化提供了重要手段。

文献Haotian Cai等, Sensors and Actuators B: Chemical, 10.1016/j.snb.2025.139418

Microchimica Acta】 Construction of a ratiometric fluorescence sensor using Mahonia fortunei leaf-derived N-CDs and Eu3+ for smartphone-assisted portable and visual monitoring of tetracycline residues in food#

摘要: 本研究利用十大功劳叶片衍生的氮掺杂碳点(N-CDs)与Eu3+结合,构建了一种比率荧光传感器。该传感器对食品中的四环素残留具有高度灵敏性,且可通过智能手机进行可视化比色分析。这种方法不仅环保且成本低廉,非常适合食品安全的便携式现场监控。

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文献Yang, Yu Zhu等, Microchimica Acta, 10.1007/s00604-025-07788-5

Inorganic Chemistry】 Metal–Organic Cage-Based Three-Channel Fluorescence Sensor Array for Discriminating Per- and Polyfluoroalkyl Substances in Water#

摘要: 针对水体中持久性有机污染物PFAS,研究者合成了金属-有机笼(NH2-Zr-MOC)。通过原位封装和修饰,构建了三通道荧光传感器阵列。该阵列利用模式识别技术实现了对三种PFAS的高灵敏度识别(检测限低至22 nM),在实际湖水及自来水样本中识别准确率达到92.5%,展现了强大的环境治理潜力。

文献Jiayi Fan等, Inorganic Chemistry, 10.1021/acs.inorgchem.5c04981

Microchemical Journal】 Dual-enhanced quantification of tetracyclines in feeds via aptamer-amplified excitation–emission matrix fluorescence and PARAFACM resolution#

摘要: 本研究提出了一种双重增强分析策略:通过DNA适配体显著提升荧光响应,结合PARAFACM算法解析复杂的三维荧光光谱。该方法成功消除了饲料样本中复杂基质的干扰,实现了对多种四环素抗生素的高灵敏定量检测,为畜牧产品安全监管提供了高效工具。

文献Yan-Ran Zhang等, Microchemical Journal, 10.1016/j.microc.2025.116769

Journal of Hazardous Materials】 Construction of self-assembled dual-ratiometric fluorescence nanoprobe for simultaneous visualization of nitrite and biogenic amines in foodstuffs and its portable intelligent sensing platforms#

摘要: 研究人员开发了基于树突状介孔有机硅(DMONs)的双比率荧光纳米探针。该探针首次实现了亚硝酸盐和尸胺(肉类新鲜度指标)的同时检测,且具有极快的响应速度(10秒内)。配合智能手机APP,该便携式平台可实现肉类新鲜度的无创实时可视化监控。

文献Yueyin Liang等, Journal of Hazardous Materials, 10.1016/j.jhazmat.2025.140992

Food Research International】 Smartphone app-enabled dual-mode fluorescence and colorimetric portable sensors using RB@BSA-AuNRs for quality identification of plant-derived products#

摘要: 研究者利用罗丹明B标记的牛血清蛋白与金纳米棒构建了双模态(荧光/比色)便携式平台。通过监测多酚诱导的荧光共振能量转移(Gate-FRET)信号变化,结合云端机器学习算法,成功实现了对中药及植物产品产地的精准追溯和质量预测,准确率高达97%。

文献Hengye Chen等, Food Research International, 10.1016/j.foodres.2025.118304

Nuclear Engineering and Design】 Carbon dots-mesoporous silica composites for efficient U(Ⅵ) adsorption and in situ fluorescence monitoring#

摘要: 本研究制备了碳点功能化的MCM-41复合材料,用于核废水中铀(U(Ⅵ))的同步吸附与荧光监测。铀的配位会导致探针荧光淬灭,这种“吸附-反馈”一体化设计为核废水的智能化处理提供了全新的解决方案。

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文献Yanan Ren等, Nuclear Engineering and Design, 10.1016/j.nucengdes.2025.114740

摘要: 利用陈皮作为生物质前驱体合成的铁掺杂碳点(Fe-CDs)展现了类过氧化物酶活性和强荧光。该平台通过智能手机拍摄颜色和荧光强度变化,实现了对剧毒污染物4-硝基苯酚的高灵敏现场检测,并具备催化降解功能。

文献Jingwen Zhong等, Diamond and Related Materials, 10.1016/j.diamond.2025.113286

Spectrochimica Acta Part A】 Iron-doped carbon dot nanozymes with fluorescence and enzyme-like activity as dual-mode sensor for the detection of tetracycline#

摘要: 该研究开发了具备蓝色荧光的铁掺杂碳点纳米酶(CDNEs)。基于四环素对CDNEs荧光及酶促活性的双重调节效应,构建了双模态分析系统。该系统在真实水样中展现了极高的灵敏度(LOD为20 nM),支持肉眼可视化的现场高通量检测。

文献Zihan Li等, Spectrochimica Acta Part A, 10.1016/j.saa.2025.127415

Materials Research Bulletin】 Fluorescence-Based Single-Sensor Platform Using Polymer-Coated CdSe/ZnS Quantum Dots for Discrimination of Isoniazid, Hydrazine, Lactose, and Pharmaceutical Tablets#

摘要: 本研究构建了基于聚合物涂层量子点(PMA-QDs)的单传感器平台。通过主成分分析(PCA)等化学计量学方法,该平台能够区分异烟肼及其毒性代谢物肼,并成功识别不同品牌的商业药片,准确率达100%,展示了其在药物质量控制方面的潜力。

文献Masoumeh Hasani等, Materials Research Bulletin, 10.1016/j.materresbull.2026.113990

Microchimica Acta】 A one-shot approach for serum vancomycin assessment using fluorescence-based molecularly imprinted polymer nanoparticles#

摘要: 为了快速评估血清中的万古霉素水平,本研究制备了嵌入荧光硫氨素的分子印迹聚合物纳米粒子(MIP NPs)。该探针可与目标抗生素特异性结合并产生荧光信号变化,实现了一次性、快速的血清监测。

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文献Chunta, Suticha等, Microchimica Acta, 10.1007/s00604-025-07798-3

Analytical and Bioanalytical Chemistry】 Rhodamine B-encapsulated MOF@boric acid-modified COF for adsorption and ratiometric fluorescence detection of baicalin#

摘要: 通过在硼酸修饰的COF框架中封装罗丹明B,研究者合成了一种MOF@COF异质结构。该材料不仅对黄芩苷具有高效的吸附能力,还能通过荧光比率信号实现对其浓度的敏感检测,兼具富集与传感双重功能。

文献Bo, Chunmiao等, Analytical and Bioanalytical Chemistry, 10.1007/s00216-025-06274-4

Microchemical Journal】 Recent advances in organic fluorescence sensors for the detection of Hg2+ and bioimaging applications: a comprehensive review#

摘要: 这篇综述详细总结了基于罗丹明、香豆素和芘等结构的有机荧光传感器在汞离子(Hg2+)检测中的最新进展。文章重点讨论了传感器在生物细胞和活体成像中的应用,特别是如何通过结构设计提高探针的选择性和生物相容性。

文献Muhanad Alhujaily等, Microchemical Journal, 10.1016/j.microc.2025.116779

Biosensors】 Magnetic Europium Ion-Based Fluorescence Sensing Probes for the Detection of Tetracyclines in Complex Samples#

摘要: Eu3+不仅具有特征荧光,还具备顺磁性。本研究利用Eu3+螯合增强原理,开发了针对四环素的磁性荧光探针,显著提高了复杂生物样本前处理后的检测效率。

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文献Miftakhul Jannatin等, Biosensors, 10.3390/bios16010029

Journal of Fluorescence】 ‌Discrimination of Triphenylmethane Drug in Aquatic Products Using Fluorescence Sensor Array Based on Rare-Earth Complexes‌#

摘要: 研究利用Eu3+和Tb3+镧系络合物构建了荧光传感器阵列,通过特异性荧光淬灭模式成功区分了水产品中多种三苯甲烷类非法添加药物。

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文献Chen, Ling等, Journal of Fluorescence, 10.1007/s10895-025-04692-2

Spectrochimica Acta Part A】 A dual-responsive ratiometric fluorescence sensor for highly sensitive detection of heparin with Eu CPs and fluorescent polydopamine nanoparticles#

摘要: 通过带负电的铕基配合物(Eu CPs)与正电荷聚多巴胺纳米粒子(FPDA NPs)的静电组装,构建了一种对肝素高度敏感的比率荧光传感器。该探针在人血清样本中展现出优异的回收率,适用于生物医学分析。

文献Yan-Zhao Fang等, Spectrochimica Acta Part A, 10.1016/j.saa.2025.127402


三、 荧光材料物理与新型器件#

Inorganic Chemistry】 Thermally Activated Delayed Fluorescence in Bridged Dinuclear Copper(I) Cluster-Based Scintillators for High-Resolution X-ray Imaging#

摘要: 本研究引入了刚性膦配体设计了一系列Cu2X2(N̂P)3(X = Cl, Br, I)配合物。这些配合物具有高效的热激活延迟荧光(TADF)特性,光致发光量子产率高达97.6%。作为闪烁体,其光输出是商业BGO晶体的2.87倍,且具有超低检测限和优异的加工稳定性。通过微电子打印技术制备的闪烁体薄膜实现了极高的X射线成像分辨率(>20 lp mm⁻¹)。

文献Qian Cao等, Inorganic Chemistry, 10.1021/acs.inorgchem.5c05184

Light: Science & Applications】 Simultaneous delayed fluorescence and phosphorescence in organic luminescent material employing multiple excited states#

摘要: 本研究报告了一种能在室温下同时产生瞬时荧光(PF)、延迟荧光(TADF)和磷光(RTP)的单组分有机发光材料。通过精准调控T2激发态的位置,实现了从紫外到深蓝的全波段发射,且磷光效率突破30%。该发现为开发多重激发态协同发光的高效率有机材料提供了核心理论支撑。

文献Dou, Dehai等, Light: Science & Applications, doi<10>.1038/s41377-025-02063-x

Advanced Optical Materials】 Extended-Range Thermometry via Dual Er Fluorescence of Oxyfluoride Glass-Ceramic Optical Fibers#

摘要: 本研究开发了掺杂Yb3+/Er3+的氟氧化物微晶玻璃光纤,通过结合绿色上转换荧光和红外荧光构建了双通道比率型温度计。该系统将测温范围扩展至800 K以上,且在光纤最低损耗波段工作,极大地便利了远距离光纤测温应用。

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文献Giulio Gorni等, Advanced Optical Materials, 10.1002/adom.202501720

Journal of Luminescence】 Fluorescence thermometry utilizing ambient light via energy transfer progression#

摘要: 提出了一种无需外置激光源、可直接由环境光激发的近红外荧光测温材料(GLGA: Cr3+, Yb3+)。通过利用Cr3+与Yb3+之间的能量转移及不同的热淬灭行为,实现了在日常阳光或室内照明下的高灵敏非接触式温度测量。

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文献Shuai He等, Journal of Luminescence, 10.1016/j.jlumin.2025.121732

ACS Applied Materials & Interfaces】 Systematic Study via Controlling the Molecular Design for Reducing the Triplet Delayed Lifetime in Thermally Activated Delayed Fluorescence Emitters for Efficient OLEDs#

摘要: 为了开发高效率、低寿命衰减的OLED发光物,研究者通过改变受体核心,对比了开放和融合结构的TADF材料。研究发现,含氮取代的开放式分子PPy-tCz具有极短的延迟寿命(116 μs)和高达26.9%的最大外部量子效率,展示了精细结构调节对器件性能的重要作用。

文献Nisha Yadav等, ACS Applied Materials & Interfaces, 10.1021/acsami.5c17734

Dyes and Pigments】 Fluorene-based gold(I)-containing AIEgens with substituents exhibiting diverse electronic effects: hypsochromic mechanofluorochromism, force-induced substantial weakening of fluorescence intensity and its anti-counterfeiting application#

摘要: 本研究制备了两种基于芴的金(I)聚集诱导发光体(AIEgens)。有趣的是,这两种分子展现了截然不同的力致变色行为:一种是蓝移荧光响应,另一种则是压力诱导的荧光强度大幅减弱。利用后者的特性,研究人员成功构建了披萨模型的信息防伪系统。

文献Shanting Liu等, Dyes and Pigments, 10.1016/j.dyepig.2025.113544

Dyes and Pigments】 Thermally activated delayed fluorescence with methyl-modified triazine acceptors for efficient organic light-emitting diodes#

摘要: 通过对三嗪受体进行甲基改性,研究者通过精细调节其电子撤回能力,实现了高达0.537 cm⁻¹的自旋-轨道耦合矩阵元和超快的反向系间窜越(RISC)过程。基于此设计的OLED器件外部量子效率突破20%,证明了细微的化学修饰能极大提升发光物性能。

文献Xiaoting Feng等, Dyes and Pigments, 10.1016/j.dyepig.2025.113543

Advanced Functional Materials】 Thermally Activated Delayed Fluorescence in Phase-Separated Nanostructures#

摘要: 研究提出利用相分离纳米结构诱导产生TADF发光。通过在受体分子上连接低聚硅氧烷链诱导自组装,形成的层状纳米结构成功产生了电荷转移(CT)配合物。这种基于空间组织的分子设计策略,为开发高性能、易加工的薄膜发光材料开辟了新路径。

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文献Bart W.L. van den Bersselaar等, Advanced Functional Materials, 10.1002/adfm.202528822

European Polymer Journal】 Isosorbide-based copolymers poly(isosorbide carbonate-co-alkylene naphthalate): Synthesis, properties and fluorescence Regulation#

摘要: 本研究合成了基于生物基单体异山梨醇的一系列共聚酯。这些共聚物在块体状态下具有本征荧光特性,且发射波长可在387-455 nm之间精确调节。作为环保、可拉伸的生物基发光塑料,展示了广阔的包装与装饰应用前景。

文献Ming-Xuan Du等, European Polymer Journal, 10.1016/j.eurpolymj.2025.114477

Journal of Fluorescence】 Design, Synthesis, and Fluorescence Properties of Bis-Schiff Base Derivatives Via Spectroscopic, Computational, and Docking Approaches#

摘要: 研究者利用芳香二胺与醛类缩合合成了一系列新型双席夫碱衍生物。通过光谱实验、计算化学及对接模拟,详细阐明了该类分子的发光机理及其与潜在靶点的相互作用过程。

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文献Rajadurai, D.等, Journal of Fluorescence, 10.1007/s10895-025-04693-1

Journal of Molecular Structure】 Emergence of supramolecular chirality and fluorescence emission shift induced by interfacial self-assembly of symmetric chiral schiff base derivatives#

摘要: 通过界面自组装技术,研究者制备了手性发光薄膜。对称的席夫碱衍生物在组装后展现出显著增强的圆二色性(CD)信号和明显的红色发光偏移,为构建高性能手性光学材料提供了方法论。

文献Meiyu Jia等, Journal of Molecular Structure, 10.1016/j.molstruc.2025.145197


四、 荧光分析前沿技术与交叉应用#

Light: Science & Applications】 Point spread function decoupling in computational fluorescence microscopy#

摘要: 本研究提出了一种点扩散函数(PSF)解耦方法,用于计算荧光显微镜的系统校准。通过利用普通荧光样本的先验信息替代传统的亚衍射颗粒进行解耦,实现了精确的非参数化系统表征。实验证明该方法在各种组织成像中表现优异,能获得媲美共焦显微镜的高对比度亚细胞结构图像。

文献Wang, Ziwei等, Light: Science & Applications, doi<10>.1038/s41377-025-02112-5

Scientific Reports】 A rigorous theoretical model of fluorescence-based fiber optic sensors: application to D-shaped fibers#

摘要: 本文建立了一个严密的荧光基光纤传感器理论模型,涵盖了多模激发和非相干发射捕捉。通过模拟分析证明,采用更高阶模态激发可以显著提升大芯径光纤的荧光输出效率,且D型光纤抛光深度在核心直径一半左右时性能最优。

文献Baghapour, Shaghayegh等, Scientific Reports, doi<10>.1038/s41598-025-33244-8

International Journal of Heat and Mass Transfer】 Heat transfer at the contact line of an evaporating meniscus observed by fluorescence thermal microscopy#

摘要: 利用荧光显微镜集成超薄温度敏感漆(TSP),研究者构建了荧光热显微镜,实现了对蒸发液滴接触线区域亚微米量级壁面温度分布的解析。实验观察到接触线附近剧烈的温度梯度和极高的局部热通量(32 kW/m²),为理解微尺度相变热质传递提供了实验证据。

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文献Kenta Hatanaka等, International Journal of Heat and Mass Transfer, 10.1016/j.ijheatmasstransfer.2025.128303

Scientific Reports】 Discovering hidden satellites in Mn K α\alpha using novel high-accuracy fluorescence, with PCA revealing evolution of quantum processes#

摘要: 研究报告了在锰金属激发发射线中发现的“隐藏卫星峰”。通过新型增程高能分辨率荧光探测(XR-HERFD)技术和主成分分析(PCA),研究揭示了多体纠缠等复杂量子过程。这一发现挑战了传统的XAFS方程,对量子力学理论及同步辐射实验技术具有深远影响。

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文献Rijal, Ramesh等, Scientific Reports, doi<10>.1038/s41598-025-33674-4

Electronics】 Cross-Modality Guided Super-Resolution for Weak-Signal Fluorescence Imaging via a Multi-Channel SwinIR Framework#

摘要: 针对弱信号荧光通道(如DAPI)信噪比低的问题,本研究提出了一种跨模态引导的超分辨率算法框架。利用多通道协同学习,该方法能有效恢复图像的边缘连续性和纹理,显著提升了生物成像的清晰度。

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文献Haoxuan Huang等, Electronics, 10.3390/electronics15010204

Remote Sensing】 Spectral Unmixing of Airborne and Ground-Based Imaging Spectroscopy for Pigment-Specific FAPAR and Sun-Induced Fluorescence Interpretation#

摘要: 本研究利用成像光谱技术对日光诱导荧光(SIF)进行解析,建立了跨尺度的光合效率评估框架。这一成果能在大范围内监测农作物的健康状态和胁迫反应。

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文献Ana B. Pascual-Venteo等, Remote Sensing, 10.3390/rs18010146

Radiation Physics and Chemistry】 Multispectral imaging and portable X-ray fluorescence spectrometry (pXRF) for studying the painting “Annunciation” (c. 1600) by El Greco#

摘要: 研究人员利用多光谱成像和便携式X射线荧光光谱(pXRF)对埃尔·格列柯的油画进行了无损研究。荧光光谱揭示了其使用的受限调色板和颜料组成,为艺术品的修复与归档提供了科学依据。

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文献Rafael Molari等, Radiation Physics and Chemistry, 10.1016/j.radphyschem.2026.113603

Spectroscopy Journal】 Portable X-Ray Fluorescence as a Proxy for Aerinite in Pigments of Medieval Alto Aragón Cultural Heritage#

摘要: 本文展示了便携式X射线荧光技术在识别中世纪艺术品中蓝色矿物颜料的应用,成功避免了传统鉴定所需的侵入性采样。

文献José Antonio Manso-Alonso等, Spectroscopy Journal, 10.3390/spectroscj4010001

Talanta】 Three-dimensional fluorescence analysis of bloodred webcap (Cortinarius sanguineus)-based dye on wool dyed with different methods#

摘要: 通过三维荧光光谱分析,研究了天然染料在羊毛纱线上的发光特性。该技术在无损鉴定历史纺织品染料来源方面表现出巨大潜力。

文献Elsa Vanker等, Talanta, 10.1016/j.talanta.2025.129334


本周核心亮点总结#

本周荧光领域展现出极强的跨学科融合趋势。在临床医学领域,NIR-II荧光探针相位分析技术显著提升了无标记成像的分子对比度,为骨折和癌症的精准诊断提供了新工具。在传感器方面,碳点、金属-有机笼与适配体的结合大幅增强了对抗生素、环境污染物(如PFAS、铀)及食品新鲜度的监控能力,特别是智能手机辅助检测的普及,标志着荧光分析正从实验室走向现场应用。

此外,在基础材料领域,TADF与磷光多重激发态的协同机制研究为下一代高效OLED器件奠定了基础;而荧光热显微成像高能分辨率荧光探测等前沿技术的应用,则不仅推动了流体力学和量子力学的理论探索,也为文化遗产保护和精准农业监测提供了创新的无损分析手段。

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荧光爱好者周刊(第三十九期)
https://blog.fluolab.cn/posts/weekly/97-2026年/26-00001/
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1
荧光爱好者周刊(第三十九期)
一、 荧光成像与临床医疗突破
【Communications Biology】 Label-free human skin imaging with enhanced molecular contrast via time-resolved fluorescence and advanced phasor analysis
【Materials Today Chemistry】 Surface engineering quantum dots emitting agents for NIR-II fluorescence imaging-guided rapid diagnosis of bone fracture
【International Journal of Colorectal Disease】 Deep impact analysis of surgical strategy changes guided by indocyanine green fluorescence angiography in laparoscopic low anterior resection for rectal cancer
【Cancers】 Recovery of IR700 Fluorescence After Near-Infrared Photoimmunotherapy: Discovery and Mechanistic Insights
【Cancers】 Fluorescence-Guided Surgery in Pediatric Oncology: Current Practice and Future Directions
【Analytical Chemistry】 Development of a Label-Free Fluorescence Strategy for Sensitive and Site-Specific Measurement of RNA Inosine Modification in Breast Tissues
【Chinese Chemical Letters】 Electronic tuning of cyanine for highly specific dual ratiometric NIR-II fluorescence/photoacoustic imaging of H2S2 in vivo
【Molecules】 Evaluation of the Performance of New Fluorescence Immunoassay POCTs for Determining the Value of Vitamin D in Whole Blood
【Microchemical Journal】 DNA-based nanomaterials for fluorescence imaging of tumor-associated biomolecules
二、 荧光传感器:环境、食品与工业检测
【Sensors and Actuators B: Chemical】 Improved laser-induced fluorescence instrument via chemical modulation for OH radical measurement: High-sensitivity detection and interference evaluation
【Microchimica Acta】 Construction of a ratiometric fluorescence sensor using Mahonia fortunei leaf-derived N-CDs and Eu3+ for smartphone-assisted portable and visual monitoring of tetracycline residues in food
【Inorganic Chemistry】 Metal–Organic Cage-Based Three-Channel Fluorescence Sensor Array for Discriminating Per- and Polyfluoroalkyl Substances in Water
【Microchemical Journal】 Dual-enhanced quantification of tetracyclines in feeds via aptamer-amplified excitation–emission matrix fluorescence and PARAFACM resolution
【Journal of Hazardous Materials】 Construction of self-assembled dual-ratiometric fluorescence nanoprobe for simultaneous visualization of nitrite and biogenic amines in foodstuffs and its portable intelligent sensing platforms
【Food Research International】 Smartphone app-enabled dual-mode fluorescence and colorimetric portable sensors using RB@BSA-AuNRs for quality identification of plant-derived products
【Nuclear Engineering and Design】 Carbon dots-mesoporous silica composites for efficient U(Ⅵ) adsorption and in situ fluorescence monitoring
【Diamond and Related Materials】 Bio-sourced Fe-doped carbon dots for dual-mode fluorescence and colorimetric sensing of 4-nitrophenol
【Spectrochimica Acta Part A】 Iron-doped carbon dot nanozymes with fluorescence and enzyme-like activity as dual-mode sensor for the detection of tetracycline
【Materials Research Bulletin】 Fluorescence-Based Single-Sensor Platform Using Polymer-Coated CdSe/ZnS Quantum Dots for Discrimination of Isoniazid, Hydrazine, Lactose, and Pharmaceutical Tablets
【Microchimica Acta】 A one-shot approach for serum vancomycin assessment using fluorescence-based molecularly imprinted polymer nanoparticles
【Analytical and Bioanalytical Chemistry】 Rhodamine B-encapsulated MOF@boric acid-modified COF for adsorption and ratiometric fluorescence detection of baicalin
【Microchemical Journal】 Recent advances in organic fluorescence sensors for the detection of Hg2+ and bioimaging applications: a comprehensive review
【Biosensors】 Magnetic Europium Ion-Based Fluorescence Sensing Probes for the Detection of Tetracyclines in Complex Samples
【Journal of Fluorescence】 ‌Discrimination of Triphenylmethane Drug in Aquatic Products Using Fluorescence Sensor Array Based on Rare-Earth Complexes‌
【Spectrochimica Acta Part A】 A dual-responsive ratiometric fluorescence sensor for highly sensitive detection of heparin with Eu CPs and fluorescent polydopamine nanoparticles
三、 荧光材料物理与新型器件
【Inorganic Chemistry】 Thermally Activated Delayed Fluorescence in Bridged Dinuclear Copper(I) Cluster-Based Scintillators for High-Resolution X-ray Imaging
【Light: Science & Applications】 Simultaneous delayed fluorescence and phosphorescence in organic luminescent material employing multiple excited states
【Advanced Optical Materials】 Extended-Range Thermometry via Dual Er Fluorescence of Oxyfluoride Glass-Ceramic Optical Fibers
【Journal of Luminescence】 Fluorescence thermometry utilizing ambient light via energy transfer progression
【ACS Applied Materials & Interfaces】 Systematic Study via Controlling the Molecular Design for Reducing the Triplet Delayed Lifetime in Thermally Activated Delayed Fluorescence Emitters for Efficient OLEDs
【Dyes and Pigments】 Fluorene-based gold(I)-containing AIEgens with substituents exhibiting diverse electronic effects: hypsochromic mechanofluorochromism, force-induced substantial weakening of fluorescence intensity and its anti-counterfeiting application
【Dyes and Pigments】 Thermally activated delayed fluorescence with methyl-modified triazine acceptors for efficient organic light-emitting diodes
【Advanced Functional Materials】 Thermally Activated Delayed Fluorescence in Phase-Separated Nanostructures
【European Polymer Journal】 Isosorbide-based copolymers poly(isosorbide carbonate-co-alkylene naphthalate): Synthesis, properties and fluorescence Regulation
【Journal of Fluorescence】 Design, Synthesis, and Fluorescence Properties of Bis-Schiff Base Derivatives Via Spectroscopic, Computational, and Docking Approaches
【Journal of Molecular Structure】 Emergence of supramolecular chirality and fluorescence emission shift induced by interfacial self-assembly of symmetric chiral schiff base derivatives
四、 荧光分析前沿技术与交叉应用
【Light: Science & Applications】 Point spread function decoupling in computational fluorescence microscopy
【Scientific Reports】 A rigorous theoretical model of fluorescence-based fiber optic sensors: application to D-shaped fibers
【International Journal of Heat and Mass Transfer】 Heat transfer at the contact line of an evaporating meniscus observed by fluorescence thermal microscopy
【Scientific Reports】 Discovering hidden satellites in Mn K α\alphaα using novel high-accuracy fluorescence, with PCA revealing evolution of quantum processes
【Electronics】 Cross-Modality Guided Super-Resolution for Weak-Signal Fluorescence Imaging via a Multi-Channel SwinIR Framework
【Remote Sensing】 Spectral Unmixing of Airborne and Ground-Based Imaging Spectroscopy for Pigment-Specific FAPAR and Sun-Induced Fluorescence Interpretation
【Radiation Physics and Chemistry】 Multispectral imaging and portable X-ray fluorescence spectrometry (pXRF) for studying the painting “Annunciation” (c. 1600) by El Greco
【Spectroscopy Journal】 Portable X-Ray Fluorescence as a Proxy for Aerinite in Pigments of Medieval Alto Aragón Cultural Heritage
【Talanta】 Three-dimensional fluorescence analysis of bloodred webcap (Cortinarius sanguineus)-based dye on wool dyed with different methods
本周核心亮点总结