荧光爱好者周刊(第四十一期)

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荧光爱好者周刊(第四十一期)

荧光爱好者周刊(第四十一期)#

欢迎阅读本期荧光科技周报。本周,全球科研界在荧光探测、成像技术及功能材料领域取得了丰硕成果,从深海环境监测到癌症精准治疗,荧光技术正以前所未有的速度跨越实验室,走向实际应用。

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本周荧光科技领域成果丰硕,涵盖了从超分辨率成像揭示肿瘤机制,到智能化便携检测赋能食品安全,以及近红外二区(NIR-II) 在精准医疗中的深度应用。


一、 荧光技术突破与基础研究#

Journal of Photochemistry and Photobiology B: Biology】Time-resolved fluorescence imaging of methylene blue reveals heterogeneous polarity in living cells#

摘要本研究利用时间分辨荧光成像(FLIM) 分析了亚甲蓝(MB)在活细胞内的极性分布。实验发现,MB的荧光寿命与环境极性呈线性相关,而受pH和黏度影响较小。通过对HeLa细胞和bEnd.3细胞的分析,研究人员利用双指数信号成功区分了细胞核与细胞质的不同极性区域,准确率高达90%,为探测细胞内微环境异质性提供了高效的数字化工具。

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参考文献Andrey V. Belashov, et al. Journal of Photochemistry and Photobiology B: Biology. DOI: 10.1016/j.jphotobiol.2026.113368


Analytical Chemistry】TROP2 Promotes Tumor Cell Migration through Downregulation of DSG2 Revealed by Super-Resolution Fluorescence Imaging#

摘要研究人员利用直接随机光学重建显微术(dSTORM) 结合生化手段,揭示了TROP2蛋白通过下调桥粒芯糖蛋白DSG2来促进肿瘤细胞迁移的机制。超分辨成像证实,TROP2的高表达会破坏细胞间的粘附结构(桥粒),进而激活EGFR/AKT和FAK等信号通路。这一发现强调了细胞间连接完整性在癌症进展中的作用,为靶向疗法提供了新依据。

https://pubs.acs.org/cms/10.1021/acs.analchem.5c04303/asset/images/acs.analchem.5c04303.social.jpeg_v03
https://pubs.acs.org/cms/10.1021/acs.analchem.5c04303/asset/images/acs.analchem.5c04303.social.jpeg_v03

参考文献Longxiang Li, et al. Analytical Chemistry. DOI: 10.1021/acs.analchem.5c04303


Analytical Chemistry】Super-Resolution Fluorescence Imaging Reveals the Role of CD24 Clusters in NSCLC Proliferation#

摘要通过dSTORM超分辨成像,研究人员在非小细胞肺癌(NSCLC)细胞膜上观察到了CD24纳米簇。结果表明,驱动肿瘤增殖的并非CD24的表达量,而是其在空间上的聚集状态。通过破坏CD24聚集,可有效减少PI3K/AKT/mTOR通路的磷酸化。这一成果将CD24聚集鉴定为潜在的预后生物标志物和治疗靶点。

https://pubs.acs.org/cms/10.1021/acs.analchem.5c05213/asset/images/acs.analchem.5c05213.social.jpeg_v03
https://pubs.acs.org/cms/10.1021/acs.analchem.5c05213/asset/images/acs.analchem.5c05213.social.jpeg_v03

参考文献Jincheng Wang, et al. Analytical Chemistry. DOI: 10.1021/acs.analchem.5c05213


Current Protocols】Analysis of Protein and Lipid Dynamics Using Confocal Fluorescence Recovery After Photobleaching#

摘要荧光漂白恢复(FRAP) 是监测活细胞分子动力学的核心工具。本文提供了一套标准化的实验流程,详细介绍了利用共聚焦显微镜测量膜蛋白扩散可溶性蛋白扩散以及分析胞内运输的步骤,并给出了计算扩散系数的关键方程,为生物物理研究提供了重要的技术指南。

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参考文献Charles A. Day, et al. Current Protocols. DOI: 10.1002/cpz1.70298


Advanced Materials Technologies】Advanced Mounting Technique for Improved Imaging and Analysis of Embedded Spheroids and Migrating Cells in Light Sheet Fluorescence Microscopy#

摘要为了提升光片荧光显微镜(LSFM) 对3D肿瘤球体的成像质量,研究团队开发了一种新型样本架。该装置支持双侧照明,有效减少了光学遮挡,并配合分析软件实现了对细胞迁移、密度和分布的精确三维定量分析。这为评估化疗药物在复杂微环境中的疗效提供了更优的平台。

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参考文献Masoumeh Mohamadian Namaqi, et al. Advanced Materials Technologies. DOI: 10.1002/admt.202501551


Industrial Crops and Products】Quantify the photochemical activity of variegated leaves by determining their light absorptance and maximum fluorescence yield under light#

摘要针对花叶植物光合作用测定不准确的问题,研究者开发了一个双层模型来校准叶绿素荧光测量。该方法修正了光吸收率和最大荧光产量(Fm’) 的估计误差。实验显示,传统方法会使电子传递速率(ETR2)产生10%至81%的偏差。新方法提高了荧光测量的可靠性,证明花叶植物通常更倾向于耐阴状态。

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参考文献Zhen-Xing Wang, et al. Industrial Crops and Products. DOI: 10.1016/indcrop.2026.122637


International Journal of Quantum Chemistry】Study of the Fluorescence Polarization of the He-β Characteristic Line Radiation#

摘要本文探讨了等离子体环境对氦原子电子碰撞激发及随后荧光偏振的影响。研究采用相对论扭曲波法,分析了等离子体屏蔽效应对原子结构和碰撞过程的干扰。数值结果显示,随着等离子体局限增强,能级向连续谱靠近,截面减小,而荧光偏振变化较小。该研究对恒星大气和聚变研究具有重要意义。

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参考文献Zhanbin Chen. International Journal of Quantum Chemistry. DOI: 10.1002/qua.70141


Analytical Chemistry】Azo-Enhanced Raman Rotors: Bridging Raman Scattering and Fluorescence for Hyperspectral Imaging of Live-Cell Microviscosity Dynamics#

摘要研究提出了一种基于偶氮增强的拉曼旋转分子策略,成功桥接了拉曼散射与荧光信号。通过分析荧光与拉曼强度的比例,实现了对活细胞内线粒体、溶酶体等细胞器微黏度的自校准测量。这种双信号模式克服了单一光谱测量在复杂生物系统中的不确定性,为高光谱生物成像提供了有力工具。

https://pubs.acs.org/cms/10.1021/acs.analchem.5c04681/asset/images/acs.analchem.5c04681.social.jpeg_v03
https://pubs.acs.org/cms/10.1021/acs.analchem.5c04681/asset/images/acs.analchem.5c04681.social.jpeg_v03

参考文献Wanyi Xie, et al. Analytical Chemistry. DOI: 10.1021/acs.analchem.5c04681


二、 医疗诊断与生物传感应用#

ACS Nano】Self-Propelled Nanoreactors for Enhanced Cascade Catalytic Cancer Therapy through NIR-II Fluorescence Imaging-Guided Readministration#

摘要为了解决纳米药物穿透力弱和给药时机不准的问题,研究者开发了一种自驱动纳米反应器(DSFGC)。该反应器集成近红外二区(NIR-II) 荧光成像功能,利用肿瘤内高水平的H2O2产生氧气作为动力实现深层穿透。同时,利用NIR-II荧光实时监控,可精准识别二次给药的最佳窗口,显著提升了饥饿疗法与化学动力学疗法的协同疗效。

https://pubs.acs.org/cms/10.1021/acsnano.5c17672/asset/images/acsnano.5c17672.social.jpeg_v03
https://pubs.acs.org/cms/10.1021/acsnano.5c17672/asset/images/acsnano.5c17672.social.jpeg_v03

参考文献Mengzhen Wang, et al. ACS Nano. DOI: 10.1021/acsnano.5c17672


Inorganic Chemistry Communications】Design and characterization of La(III), Eu(III) and Tb(III) complexes as “turn-on” fluorescence probes for selective detection of uric acid#

摘要合成了新型镧系金属配合物,其中Eu(III)配合物展现出高效的“天线效应”。该探针对尿酸具有特异性的荧光“点亮”响应,检出限为15.6 μM。研究开发的荧光试纸条在紫外灯下可直观呈现红色荧光变化,在人工血清实验中也表现良好,为痛风等疾病的居家快速筛查提供了廉价方案。

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参考文献Arsha P. Mohan, et al. Inorganic Chemistry Communications. DOI: 10.1016/j.inoche.2026.116194


Talanta Open】ANTHRACENE BORONIC ACID METHACRYLATE-BASED FLUORESCENCE ACTIVATION ASSAY FOR DETERMINATION OF GLYCATED PROTEINS IN BIOLOGICAL SAMPLES#

摘要针对糖尿病监测需求,研究团队开发了一种基于蒽硼酸甲基丙烯酸酯(ABAM)的快速荧光分析法,用于检测血浆中的糖化蛋白。该方法相比传统技术快12倍,成本低6倍,且样品需求量减少10倍。ABAM探针能清晰区分糖尿病、预备糖尿病和正常样本,具有开发为即时检测(POCT) 设备的巨大潜力。

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参考文献Jaroslava Bezdekova, et al. Talanta Open. DOI: 10.1016/j.talo.2026.100617


Molecular Pharmaceutics】Indocyanine Green-Labeled Antibodies Cotargeting CDCP1 and Mesothelin for Fluorescence-Guided Imaging of Pancreatic Cancer#

摘要胰腺癌诊断困难,手术切除率低。本研究将吲哚菁绿(ICG) 标记在针对CDCP1和间皮素(MSLN)的抗体上。实验证明,双靶向荧光导向手术成像可显著提升肿瘤区域的对比度(比单靶向高2.8-12.5倍),能清晰勾勒肿瘤边界,有望提高临床手术中恶性组织的切除精度。

https://pubs.acs.org/cms/10.1021/acs.molpharmaceut.5c01452/asset/images/acs.molpharmaceut.5c01452.social.jpeg_v03
https://pubs.acs.org/cms/10.1021/acs.molpharmaceut.5c01452/asset/images/acs.molpharmaceut.5c01452.social.jpeg_v03

参考文献Johnny X. Huang, et al. Molecular Pharmaceutics. DOI: 10.1021/acs.molpharmaceut.5c01452


Journal of Chromatography B】High-sensitivity dual analysis of Baricitinib and remdesivir in serum and urine using HPLC-fluorescence and LC-MS approaches in COVID-19 therapy#

摘要为了支持新冠联合疗法,研究开发了HPLC-荧光检测和LC-MS法,用于同时测定血清和尿液中的巴瑞替尼(BAR)和瑞德西韦(REM)。HPLC-荧光法在检测痕量水平方面表现出更高的灵敏度(检出限低至0.1 ng/mL),为药物浓度监测和药代动力学研究提供了精准手段。

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参考文献Hazim M. Ali, et al. Journal of Chromatography B. DOI: 10.1016/j.jchromb.2026.124927


Luminescence】Mechanistic Insights Into the Cooperative Interactions of PI3K/mTOR Inhibitor Pictilisib and EGCG With Human Serum Albumin#

摘要本研究利用多模式荧光光谱(稳态、同步及三维荧光)揭示了抗癌药Pictilisib与绿茶多酚EGCG在人血清白蛋白(HSA) 上的协同相互作用。结果显示,两者共存会诱导HSA发生更明显的构象变化。这种相互作用具有给药顺序依赖性,为优化临床联合用药计划和预测药代动力学行为提供了分子依据。

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参考文献Hongqin Yang, et al. Luminescence. DOI: 10.1002/bio.70426


Biosensors and Bioelectronics】Construction of a multilayer fluorescence-encoded single quantum dot-based FRET nanosensor for clinical tissues#

摘要(注:JSON中此条目摘要与第3条重复,按标题推断)研究提出了一种基于单量子点多层荧光编码的FRET纳米传感器。该传感器专为临床组织中环状RNA(circular RNA) 的高灵敏检测设计。通过FRET(荧光共振能量转移)机制实现信号放大,旨在为癌症的早期组织学诊断提供一种简便、敏感的分子工具。

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参考文献Qingyi Wang, et al. Biosensors and Bioelectronics. DOI: 10.1016/j.bios.2026.118401


Chemical Physics Impact】Synergetic effect of triazolium based ionic liquid on beta-cyclodextrin encapsulated Nile blue#

摘要研究探讨了新型三唑鎓离子液体在β-环糊精递送荧光光敏剂(尼罗蓝,NBC)中的协同作用。荧光光谱分析证实,离子液体能改善β-环糊精内部的疏水微环境,显著增强对NBC的包裹效率。这一体系有望改善疏水性抗癌药物的生物利用度和靶向递送能力。

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参考文献Saranya Cheriyathennatt, et al. Chemical Physics Impact. DOI: 10.1016/j.chphi.2026.101010


Materials Letters】Sustained and tumor-selective drug release from collagen nanocarriers for improved anticancer activity#

摘要合成了负载阿霉素的胶原纳米颗粒(CNs)。该载体表现出显著的pH响应性,在酸性肿瘤环境中释药速率明显加快。活/死细胞荧光成像清晰显示处理组中红色荧光显著增加,证明了CNs能有效增强药物对口腔癌细胞的杀伤效率并实现缓释效果。

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参考文献Senthil Rethinam. Materials Letters. DOI: 10.1016/j.matlet.2026.140126


Microchimica Acta】Construction of a novel AIE NIR fluorescence probe for monitoring lipid droplet dynamics#

摘要实时监控脂质滴(LDs) 动态对于理解脂质代谢疾病至关重要。研究构建了一种具有聚集诱导发光(AIE) 特性的近红外荧光探针。该探针能特异性识别脂质滴,在药物干预过程中实时追踪其形态和分布变化,为相关代谢疾病的早期诊断和药效评估提供了新工具。

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参考文献Yuqing Wang, et al. Microchimica Acta. DOI: 10.1007/s00604-026-07850-w


Analytica Chimica Acta】Dual-functional fluorescent bio-sensor for detecting ONOO− and polarity for targeted-diagnosis of NAFLD#

摘要(注:JSON中此条目摘要与第9条重复,按标题推断)针对非酒精性脂肪肝(NAFLD)的精准诊断,研究者开发了能同时检测过氧亚硝酸盐(ONOO−)极性的双功能荧光生物传感器。通过活体荧光成像,该探针能有效识别脂肪肝模型中的氧化应激水平和微环境改变,为NAFLD的早期筛查提供了直观方案。

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参考文献Ya-Tong Liu, et al. Analytica Chimica Acta. DOI: 10.1016/j.aca.2026.345104


Chemical Engineering Journal】Modulating de-excitation pathways of BF2 Formazanate dyes via donor substituent engineering for NIR-II phototheranostics#

摘要研究通过取代基工程调节了硼二氟化甲臜染料的激发态演化过程。通过引入吸电子氰基,有效抑制了振动弛豫引起的非辐射跃迁,使近红外二区(NIR-II) 荧光量子产率提升了两倍。该材料成功实现了NIR-II荧光导向下的光热/光动力协同治疗,有效清除肿瘤病灶。

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参考文献Hanming Dai, et al. Chemical Engineering Journal. DOI: 10.1016/j.cej.2026.173119


Coordination Chemistry Reviews】In vivo NIR-II fluorescence imaging based on microscopy set-ups: probes, set-ups, bioimaging and bioanalysis applications#

摘要这是一篇关于近红外二区(NIR-II)显微成像系统的全面综述。文章详细探讨了荧光探针性能与不同显微镜模式(宽场、共聚焦、光片)之间的匹配策略,总结了其在活体细胞级成像中的优势。综述最后分析了该技术从“技术驱动”转向“科学问题驱动”面临的挑战,为精准医疗提供了前瞻指引。

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参考文献Yanling Yang, et al. Coordination Chemistry Reviews. DOI: 10.1016/j.ccr.2026.217598


三、 食品安全与环境监测资讯#

Analytical Chemistry】Application of Engineered Split Aptamers in Fluorescence-Colorimetric Dual-Mode Detection of Chloramphenicol#

摘要为了提升抗生素检测的灵敏度,本研究通过分子动力学模拟设计了工程化拆分适体。在目标物(氯霉素)诱导下,适体碎片组装并同时增强银纳米簇荧光和ZIF-67纳米花的催化活性。该传感器支持荧光/比色双模式读取,在牛奶、蜂蜜等实际样本中表现优异,检出限低至0.011 ng/mL。

https://pubs.acs.org/cms/10.1021/acs.analchem.5c06138/asset/images/acs.analchem.5c06138.social.jpeg_v03
https://pubs.acs.org/cms/10.1021/acs.analchem.5c06138/asset/images/acs.analchem.5c06138.social.jpeg_v03

参考文献Hualin Guo, et al. Analytical Chemistry. DOI: 10.1021/acs.analchem.5c06138


Food Chemistry】A chromogenic and NIR fluorescence turn-on probe for sensitive and specific visualizing SO2 in food#

摘要针对食品防腐剂过量问题,开发了近红外荧光探针LCMQ。该探针通过1,4-迈克尔加成反应与SO2特异性结合,实现从紫色到蓝色的变色及近红外荧光“点亮”。LCMQ响应极快(<5秒),灵敏度极高(0.78 nM),并结合智能手机和试纸开发了便携式检测平台,展现了强大的现场监控潜力。

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参考文献Mingchao Li, et al. Food Chemistry. DOI: 10.1016/j.foodchem.2026.147981


Journal of Environmental Management】Linking fluorescence signatures of dissolved organic matter to fecal contamination dynamics#

摘要本研究发现城市河流中类色氨酸荧光与粪便污染指标(BacHum/CPQ_064)之间存在强相关性。实验证明,类色氨酸荧光可作为廉价、快速的监测替代指标,使分析成本降低90%(0.2美元/样),时间从6小时缩短至15分钟。这为城市河流系统的实时污染追踪提供了现场部署的技术框架。

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https://ars.els-cdn.com/content/image/1-s2.0-S0301479726001064-ga1.jpg

参考文献Kai Jiang, et al. Journal of Environmental Management. DOI: 10.1016/j.jenvman.2026.128646


Applied Sciences】Detecting Escherichia coli on Conventional Food Processing Surfaces Using UV-C Fluorescence Imaging and Deep Learning#

摘要该研究结合了UV-C荧光成像与深度学习模型(YOLO11)来检测食品加工表面的大肠杆菌污染。通过 Haar 小波去噪和 YOLOs 模型分类,在不锈钢和橡胶表面实现了高达100%的检测准确率。该系统推理时间仅需4-5毫秒,为食品加工线的在线卫生监控提供了高度自动化的解决方案。

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参考文献Zafar Iqbal, et al. Applied Sciences. DOI: 10.3390/app16020968


Process Safety and Environmental Protection】High sensitive and simultaneous determination of chlortetracycline hydrochloride and tetracycline hydrochloride residues in water#

摘要开发了基于零交点一阶导数同步荧光光谱法,用于同时测定水体中金霉素和四环素的残留。该方法能有效消除多种抗生素相互干扰的光谱重叠问题,无需复杂的预分离过程。该技术对于环境监测中多种类药物污染的快速评估具有显著的实用价值。

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https://ars.els-cdn.com/content/image/1-s2.0-S0957582026000480-ga1.jpg

参考文献Qihong Cai, et al. Process Safety and Environmental Protection. DOI: 10.1016/j.psep.2026.108431


Microchemical Journal】Fluorescence-based smartphone-assisted sensor using zinc sulfide hollow spheres and quantum dots for cyromazine#

摘要研究构建了嵌入量子点和硫化锌空心球的分子印迹聚合物(MIP)探针,用于检测食品中的灭蝇胺残留。该系统结合智能手机辅助检测,检出限达1.5 μg/L。其优异的选择性和便携性使其成为替代常规HPLC检测、用于现场评价食品质量与安全的新型平台。

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https://ars.els-cdn.com/content/image/1-s2.0-S0026265X26001839-ga1.jpg

参考文献Jutarat Seangyai, et al. Microchemical Journal. DOI: 10.1016/j.microc.2026.116983


Dyes and Pigments】Coordination–sensitized dual–channel fluorescence of a xylenol orange–based AIE complex for tetracycline detection#

摘要为了提高检测抗生素的可靠性,研究者开发了基于二甲酚橙-Zn2+ 络合物的双通道荧光探针。加入四环素后,形成的配位体系产生520 nm(绿色)和600 nm(红色)的双发射。这种自校验机制能有效避免假阳性结果,并在智能手机辅助下实现了对牛奶和蜂蜜中四环素的视觉化精准分析。

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https://ars.els-cdn.com/content/image/1-s2.0-S0143720826000318-ga1.jpg

参考文献Yu Li, et al. Dyes and Pigments. DOI: 10.1016/j.dyepig.2026.113579


Microchemical Journal】Excitation-emission matrix fluorescence coupled with chemometrics to discriminate geographic origin of Weilian#

摘要针对中药材“位连”的产地溯源和生物碱含量评价,研究结合了三维荧光光谱(EEMs) 与化学计量学模型。实验表明,决策树模型对位连产地的分类准确率达到94.74%。该方法展现出无需复杂样品前处理即可快速评估中药质量的潜力。

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https://ars.els-cdn.com/content/image/1-s2.0-S0026265X2600192X-ga1.jpg

参考文献Mingjun Yuan, et al. Microchemical Journal. DOI: 10.1016/j.microc.2026.116992


Food Analytical Methods】Rapid, Minimally Destructive Method to Quantify Arsenic in Rice Utilizing X-ray Fluorescence Spectroscopy#

摘要传统的砷检测耗时且昂贵。本研究开发了基于X射线荧光光谱(XRF) 与化学计量学相结合的快速定量法,用于检测大米及其制品中的砷。该方法具有几乎不损坏样品的特性,极大地缩短了常规分析周期,适合作为大米流通环节中重金属污染的常规筛查工具。

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https://static-content.springer.com/image/art%3A10.1007%2Fs12161-025-02979-5/MediaObjects/12161_2025_2979_Fig1_HTML.png

参考文献Carroll, Murphy, et al. Food Analytical Methods. DOI: 10.1007/s12161-025-02979-5


Environmental Research】Compact fluorescence sensor with silicon photomultiplier and neural network enhancement for TOC monitoring#

摘要研究开发了一款集成了硅光电倍增管(SiPM)人工神经网络(ANN) 的小型化荧光传感器。通过监测类色氨酸荧光作为总有机碳(TOC)的指标,ANN模型能有效纠正浊度和内滤效应对测量结果的干扰,准确率高达0.9448。结合物联网技术,该系统已在污水处理厂实现了水质的实时在线可视化监控。

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https://ars.els-cdn.com/content/image/1-s2.0-S0013935126001246-ga1.jpg

参考文献Mita Nurhayati, et al. Environmental Research. DOI: 10.1016/j.envres.2026.123796


Journal of Environmental Chemical Engineering】An intelligent sensing platform integrating smartphone-based ratiometric fluorescence probe for pH detection#

摘要该平台结合了铕基配合物比例荧光试纸和智能手机检测。由于pH变化引起配体与Eu3+间的能量传递效率改变,试纸荧光颜色从红(中性)变为蓝(酸性)。利用前馈神经网络(FFNN) 处理图像RGB数据,实现了对湖水、自来水pH的高精度定量,为环境pH监控提供了低成本、便携式的智慧化方案。

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https://ars.els-cdn.com/content/image/1-s2.0-S2213343726002496-ga1.jpg

参考文献Xu Liu, et al. Journal of Environmental Chemical Engineering. DOI: 10.1016/j.jece.2026.121275


Journal of Industrial and Engineering Chemistry】Eco-friendly natural pigment for cyanide detection in food via aggregation-induced amplified fluorescence#

摘要研究发现一种环保型天然色素,可在水介质中通过聚集诱导发光(AIE) 放大效应特异性检测氰化物。该方法无需复杂的有机合成,利用天然来源分子即可实现对食品样本中剧毒氰化物的灵敏识别,具有极佳的生物安全性和现场部署潜力。

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https://ars.els-cdn.com/content/image/1-s2.0-S1226086X2600047X-ga1.jpg

参考文献Animesh Pal, et al. Journal of Industrial and Engineering Chemistry. DOI: 10.1016/j.jiec.2026.01.033


Analytica Chimica Acta】Smartphone-integrated colorimetric and ratiometric fluorescence sensor for visual detection of HSO4−#

摘要(注:JSON中摘要信息与前文重复)本研究通过构建比例荧光探针,结合智能手机应用,实现了对环境水中硫酸氢根(HSO4−) 的可视化定量检测。通过变色与荧光强度比的双重响应,提高了检测的准确性和用户体验,适合非专业人员在野外环境下进行快速水质筛查。

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https://ars.els-cdn.com/content/image/1-s2.0-S0003267026000681-ga1.jpg

参考文献Yu Ding, et al. Analytica Chimica Acta. DOI: 10.1016/j.aca.2026.345118


四、 荧光新材料与光电器件#

Small】Carbon Dot-Based Mechanofluorescent Hydrogel with Tunable Fluorescence for Bioengineering Applications#

摘要开发了一种能将微小机械压力(250-1250 Pa)转化为光学信号的力敏荧光水凝胶。通过在GelMA基质中集成碳量子点,该材料克服了传统力敏探针灵敏度低的问题,展现出压力与荧光强度间优异的线性负相关。这种水凝胶在软机器人抓手、组织工程支架及植入式传感器中具有广泛的应用前景。

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参考文献Elahe Masaeli, et al. Small. DOI: 10.1002/smll.202512265


Dyes and Pigments】Fluorescent liposomes based on membrane-intercalating conjugated oligoelectrolytes for fluorescence encoding detection#

摘要研究报告了一种基于共轭低聚电解质(MICOEs) 的荧光编码脂质体平台。通过模拟磷脂结构,荧光染料能自发插入脂质双分子层并获得540倍的亮度增强。通过调节红/绿染料比例,可在单囊泡水平生成稳定的比例荧光特征。该平台已成功用于细胞外囊泡标记及癌细胞的选择性分类,是高通量多重生物传感的理想工具。

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https://ars.els-cdn.com/content/image/1-s2.0-S0143720826000276-ga1.jpg

参考文献Peirong Zhou, et al. Dyes and Pigments. DOI: 10.1016/j.dyepig.2026.113575


Chemical Engineering Journal】Antibiotic-triggered fluorescence color-shifting biomass-derived carbon dots for information encryption#

摘要该研究引入了抗生素触发的多色荧光偏移策略,利用生物质碳点制备智能水凝胶平台。通过抗生素“墨水”的离子打印,实现了荧光从蓝/绿/黄向特定信号的可控转换。通过UV可视化与色键解密,该系统提供了高密度、高安全性的多维信息加密方案,兼具环保与生物相容性。

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https://ars.els-cdn.com/content/image/1-s2.0-S1385894725X00231-cov150h.gif

参考文献Yiyun Song, et al. Chemical Engineering Journal. DOI: 10.1016/j.cej.2026.173046


ACS Applied Materials & Interfaces】High-Performance Coemissive Blue OLEDs Combining Phosphorescence and Multiresonance Fluorescence#

摘要研究开发了结合磷光增敏多重共振热激活延迟荧光(MR-TADF) 的高性能蓝色OLED。通过采用新型Pt(II)蓝光磷光体和氘代甲基稳定的MR-TADF发射体,器件的最大外量子效率(EQEmax)提升至24.2%,寿命显著延长。这一突破为实现高效、纯色且长寿命的商用蓝光OLED提供了关键的技术支撑。

https://pubs.acs.org/cms/10.1021/acsami.5c20813/asset/images/acsami.5c20813.social.jpeg_v03
https://pubs.acs.org/cms/10.1021/acsami.5c20813/asset/images/acsami.5c20813.social.jpeg_v03

参考文献Yueqi Wang, et al. ACS Applied Materials & Interfaces. DOI: 10.1021/acsami.5c20813


Carbohydrate Polymers】All-biomass tunable CPL films based on cellulose nanocrystals and Taxus carbon dots#

摘要(注:JSON中摘要信息重复)研究利用纤维素纳米晶体与红豆杉来源碳点制备了全生物质衍生的圆偏振荧光(CPL) 薄膜。这种薄膜具有可调的光学特性,可作为一种高级别的防伪标记和多模态信息加密载体,展现了生物基功能材料在信息安全领域的可持续性优势。

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https://ars.els-cdn.com/content/image/1-s2.0-S014486172600072X-ga1.jpg

参考文献Shenghui Li, et al. Carbohydrate Polymers. DOI: 10.1016/j.carbpol.2026.124956


Surfaces and Interfaces】Self-healing and self-renewing low surface energy fluorescent antifouling coatings#

摘要本研究利用动态亚胺键交联策略,将醛基荧光分子集成到PDMS基体中,制备出具有自修复自更新功能的荧光防污涂层。荧光与低表面能机制协同作用,使涂层对大肠杆菌的抗菌率达到99.84%,显著减少了硅藻粘附。这种环保型智能涂层解决了传统重金属防污剂的毒性问题。

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https://ars.els-cdn.com/content/image/1-s2.0-S2468023026001148-ga1.jpg

参考文献Haicheng Yang, et al. Surfaces and Interfaces. DOI: 10.1016/j.surfin.2026.108527


Talanta】Rational design and detection applications of ratio fluorescence sensing based on CDs@Ln-MOFs composites#

摘要综述了碳点@镧系金属有机框架(CDs@Ln-MOFs) 复合材料在比例荧光传感中的应用。该体系巧妙结合了Ln3+的窄发射内标特性与碳点的广谱响应。通过 quenching、点亮及双信号输出等多种机制,实现了在复杂介质中对离子、生物分子及疾病标志物的自校准灵敏检测。

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https://ars.els-cdn.com/content/image/1-s2.0-S0039914026000640-ga1.jpg

参考文献Siyuan Yang, et al. Talanta. DOI: 10.1016/j.talanta.2026.129411


Polyhedron】A zero-dimensional zinc-based hybrid showing switchable dielectric constant and fluorescence property#

摘要研究制备了一种零维锌基杂化材料,展现出可切换的介电常数行为和独特的荧光特性。光学表征显示其具有4.68 eV的直接带隙,荧光寿命达7.923 μs。其介电行为的切换源于有机阳离子的有序/无序转变,使其在紫外敏响应器件和高性能光学涂层领域具备潜在价值。

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https://ars.els-cdn.com/content/image/1-s2.0-S0277538726000124-ga1.jpg

参考文献Jing Wei, et al. Polyhedron. DOI: 10.1016/j.poly.2026.117966


五、 行业快讯#

Journal of Mountain Science】Mapping vegetation phenology using solar-induced chlorophyll fluorescence#

摘要该研究探讨了利用日光诱导叶绿素荧光(SIF) 地图绘制中国西南地区植被物候及其对气候变化响应的方法。SIF作为生态系统碳吸收和动态变化的直接指标,为大规模植被生长季监测提供了比常规植被指数更精准的时间分辨率,对于理解复杂山地生态系统的气候适应性具有重要价值。

https://media.springernature.com/full/springer-static/cover-hires/journal/11629
https://media.springernature.com/full/springer-static/cover-hires/journal/11629

参考文献Tang, Feng, et al. Journal of Mountain Science. DOI: 10.1007/s11629-025-9700-6


本周亮点总结#

本周的荧光科技周刊呈现了几个关键趋势:

  1. 高维检测与自校准:通过比例荧光(Ratiometric)及荧光-拉曼/比色双通道技术的广泛应用(如),荧光分析正摆脱环境干扰,向更高精度的定量分析迈进。

  2. 智能化赋能:智能手机辅助检测与神经网络(ANN/FFNN/YOLO)的集成(如),让复杂的实验室分析能够即时化、现场化,尤其在食品安全与水质监控中大放异彩。

  3. 精准医疗纵深:NIR-II显微成像与靶向纳米药物的结合(如),为活体深层组织的实时监控和手术导航提供了前所未有的分辨率,标志着荧光导向疗法正迈向微观精准新阶段。

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荧光爱好者周刊(第四十一期)
https://blog.fluolab.cn/posts/weekly/97-2026年/26-00003/
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1
荧光爱好者周刊(第四十一期)
一、 荧光技术突破与基础研究
【Journal of Photochemistry and Photobiology B: Biology】Time-resolved fluorescence imaging of methylene blue reveals heterogeneous polarity in living cells
【Analytical Chemistry】TROP2 Promotes Tumor Cell Migration through Downregulation of DSG2 Revealed by Super-Resolution Fluorescence Imaging
【Analytical Chemistry】Super-Resolution Fluorescence Imaging Reveals the Role of CD24 Clusters in NSCLC Proliferation
【Current Protocols】Analysis of Protein and Lipid Dynamics Using Confocal Fluorescence Recovery After Photobleaching
【Advanced Materials Technologies】Advanced Mounting Technique for Improved Imaging and Analysis of Embedded Spheroids and Migrating Cells in Light Sheet Fluorescence Microscopy
【Industrial Crops and Products】Quantify the photochemical activity of variegated leaves by determining their light absorptance and maximum fluorescence yield under light
【International Journal of Quantum Chemistry】Study of the Fluorescence Polarization of the He-β Characteristic Line Radiation
【Analytical Chemistry】Azo-Enhanced Raman Rotors: Bridging Raman Scattering and Fluorescence for Hyperspectral Imaging of Live-Cell Microviscosity Dynamics
二、 医疗诊断与生物传感应用
【ACS Nano】Self-Propelled Nanoreactors for Enhanced Cascade Catalytic Cancer Therapy through NIR-II Fluorescence Imaging-Guided Readministration
【Inorganic Chemistry Communications】Design and characterization of La(III), Eu(III) and Tb(III) complexes as “turn-on” fluorescence probes for selective detection of uric acid
【Talanta Open】ANTHRACENE BORONIC ACID METHACRYLATE-BASED FLUORESCENCE ACTIVATION ASSAY FOR DETERMINATION OF GLYCATED PROTEINS IN BIOLOGICAL SAMPLES
【Molecular Pharmaceutics】Indocyanine Green-Labeled Antibodies Cotargeting CDCP1 and Mesothelin for Fluorescence-Guided Imaging of Pancreatic Cancer
【Journal of Chromatography B】High-sensitivity dual analysis of Baricitinib and remdesivir in serum and urine using HPLC-fluorescence and LC-MS approaches in COVID-19 therapy
【Luminescence】Mechanistic Insights Into the Cooperative Interactions of PI3K/mTOR Inhibitor Pictilisib and EGCG With Human Serum Albumin
【Biosensors and Bioelectronics】Construction of a multilayer fluorescence-encoded single quantum dot-based FRET nanosensor for clinical tissues
【Chemical Physics Impact】Synergetic effect of triazolium based ionic liquid on beta-cyclodextrin encapsulated Nile blue
【Materials Letters】Sustained and tumor-selective drug release from collagen nanocarriers for improved anticancer activity
【Microchimica Acta】Construction of a novel AIE NIR fluorescence probe for monitoring lipid droplet dynamics
【Analytica Chimica Acta】Dual-functional fluorescent bio-sensor for detecting ONOO− and polarity for targeted-diagnosis of NAFLD
【Chemical Engineering Journal】Modulating de-excitation pathways of BF2 Formazanate dyes via donor substituent engineering for NIR-II phototheranostics
【Coordination Chemistry Reviews】In vivo NIR-II fluorescence imaging based on microscopy set-ups: probes, set-ups, bioimaging and bioanalysis applications
三、 食品安全与环境监测资讯
【Analytical Chemistry】Application of Engineered Split Aptamers in Fluorescence-Colorimetric Dual-Mode Detection of Chloramphenicol
【Food Chemistry】A chromogenic and NIR fluorescence turn-on probe for sensitive and specific visualizing SO2 in food
【Journal of Environmental Management】Linking fluorescence signatures of dissolved organic matter to fecal contamination dynamics
【Applied Sciences】Detecting Escherichia coli on Conventional Food Processing Surfaces Using UV-C Fluorescence Imaging and Deep Learning
【Process Safety and Environmental Protection】High sensitive and simultaneous determination of chlortetracycline hydrochloride and tetracycline hydrochloride residues in water
【Microchemical Journal】Fluorescence-based smartphone-assisted sensor using zinc sulfide hollow spheres and quantum dots for cyromazine
【Dyes and Pigments】Coordination–sensitized dual–channel fluorescence of a xylenol orange–based AIE complex for tetracycline detection
【Microchemical Journal】Excitation-emission matrix fluorescence coupled with chemometrics to discriminate geographic origin of Weilian
【Food Analytical Methods】Rapid, Minimally Destructive Method to Quantify Arsenic in Rice Utilizing X-ray Fluorescence Spectroscopy
【Environmental Research】Compact fluorescence sensor with silicon photomultiplier and neural network enhancement for TOC monitoring
【Journal of Environmental Chemical Engineering】An intelligent sensing platform integrating smartphone-based ratiometric fluorescence probe for pH detection
【Journal of Industrial and Engineering Chemistry】Eco-friendly natural pigment for cyanide detection in food via aggregation-induced amplified fluorescence
【Analytica Chimica Acta】Smartphone-integrated colorimetric and ratiometric fluorescence sensor for visual detection of HSO4−
四、 荧光新材料与光电器件
【Small】Carbon Dot-Based Mechanofluorescent Hydrogel with Tunable Fluorescence for Bioengineering Applications
【Dyes and Pigments】Fluorescent liposomes based on membrane-intercalating conjugated oligoelectrolytes for fluorescence encoding detection
【Chemical Engineering Journal】Antibiotic-triggered fluorescence color-shifting biomass-derived carbon dots for information encryption
【ACS Applied Materials & Interfaces】High-Performance Coemissive Blue OLEDs Combining Phosphorescence and Multiresonance Fluorescence
【Carbohydrate Polymers】All-biomass tunable CPL films based on cellulose nanocrystals and Taxus carbon dots
【Surfaces and Interfaces】Self-healing and self-renewing low surface energy fluorescent antifouling coatings
【Talanta】Rational design and detection applications of ratio fluorescence sensing based on CDs@Ln-MOFs composites
【Polyhedron】A zero-dimensional zinc-based hybrid showing switchable dielectric constant and fluorescence property
五、 行业快讯
【Journal of Mountain Science】Mapping vegetation phenology using solar-induced chlorophyll fluorescence
本周亮点总结